Yi-Hsiang Hsu, M.D., ScD
Director of the Genetic Epi Program, HSL Institute for Aging Research Beth Israel Deaconess Medical Center and Harvard Medical School
Dr. Yi-Hsiang Hsu is the Director of the Genetic Epi Program at HSL Institute for Aging Research and Harvard Medical School. He is a faculty at the Broad Institute of MIT and Harvard, as well as at Harvard Medical School and at Program for Quantitative Genomics, Program of Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, MA.
Dr. Hsu is a Statistical Geneticist/Computational Biologist. His research focuses on (1) Genetic contribution of common aging relevant disorders (such as osteoporosis, sarcopenic obesity, metabolic syndrome, type 2 diabetes and hypertension) using population-based next generation (NGS) whole genome sequencing, exome-sequencing and genome-wide association (GWAS) approaches to identify common and rare variants that are associated with these complex traits/phenotypes; (2) Predicting non-coding causal variants and targeted genes in GWAS loci using tissue-and cell-specific gene regulatory landscapes generated by ENCODE and US NIH Roadmap Epigenomics Project; (3) Statistical method development on multiple-phenotype association analyses; (4) Integrating omics data (genomics, transcriptome, epigenomics, proteomics and metabolomics) using system genetics and bioinfomatic approaches; and (5) Identifying biomarkers of osteoporosis using metabolomics.