Technology: Platform
Lab Platform
Novogene has genomic sequencing labs in the US at The University of California at Davis campus, China, Singapore and the UK (Cambridge), with a total area of nearly 20,000 ㎡, including a 2,000 ㎡ GMP facility and a 2,000 ㎡ clinical laboratory.
Novogene UC Davis Sequencing Center was founded in early 2016, equipped with the NovaSeq 6000, HiSeq X Ten, and HiSeq 4000 sequencing platforms to serve customers in North and South America. Next generation sequencing services and analysis of human, plant, and animal samples are offered for both research and clinical purposes.
Novogene Cambridge Genomic Sequencing Centre, the first European sequencing centre of Novogene Europe, was established at Babraham Research Campus in May 2018, and relocated to Cambridge Science Park in August 2019 due to rapid business expansion. The Centre is now equipped with automatic workstations, multiple NovaSeq 6000s, and High-Performance Computing Clusters.
Novogene has successfully established a CAP-accredited medical lab in Tianjin, China. This world class facility enables us to provide high-quality clinical sequencing services globally. The Tianjin lab also provides solutions to test liquid biopsy samples using Novogene’s digital PCR platform. In partnership with AITbiotech, Novogene has also launched a genomics center in Singapore to deliver NGS services in Asia Pacific, Middle East and Africa
Sequencing Platform
Illumina Novaseq Platform
NovaSeq 6000
Introduced by Illumina in January 2017, the NovaSeq Sequencer provides tremendous scalability and flexibility to accommodate diverse applications and project sizes, for virtually any sequencing method, genome, and scale of project. The NovaSeq sequencer extends applications previously unavailable on HiSeq X Ten, such as expression profiling, whole transcriptome analysis, microbial genome, WES, low pass WGS, etc., while accommodating rapid turnaround, flexible configurations and cost effectiveness. The addition of these NovaSeq sequencers not only expands Novogene’s sequencing capacity, but also greatly reduces our sequencing turnaround time. With the NovaSeq, we are able to sequence up to 48 human whole genomes and produce 6Tb of data per single run as short as 40 hours.
System specifications:
850G raw data per lane, 3.4T raw data per Flowcell and 2 x 150 bp read length;
800M raw reads per Flowcell and 2 x 250 bp & 2 x 50 bp reads length;
Nanopore Platform
Nanopore PromethION
Oxford Nanopore Technologies offers real-time, long-read, direct and large-scale sequencing of DNA or RNA. Novogene acquired Nanopore PromethION System, the most updated version of Nanopore sequencers with the highest throughput, in 2018. The PromethION system sequences DNA or RNA by Nanopore reader proteins embedded in an electrically resistant membrane. Ultra-long reads span repeat regions in complicated genomes easily, and enhance accuracy of genome assembly and large structure variation detection enormously.
Pacbio Sequel Platform
Pacbio Sequel
The PacBio Sequel System is the SMRT sequencing platform that provides ultra-long sequencing reads with high consensus accuracy, uniform coverage, and simultaneous epigenetic characterization at single-molecule resolution. The PacBio Sequel System provides 7x more throughput, more scalability, and lower sequencing costs than the PacBio RS II System, while maintaining the same benefits. With the addition of the PacBio Sequel Systems that Novogene acquired in early 2017, Novogene now has the world’s largest SMRT sequencing capacity.
Illumina HiSeq Platform
HiSeq 4000 / 2500 / 2000
HiSeq Sequencing System combine illumina’s proven and widely adopted, reversible terminator-based sequencing by synthesis chemistry with innovative engineering. The whole series have industry-leading accuracy and unprecedented output, breakthrough use experiences, unmateched Cost-Effectiveness, and flexibility. Novogene is equipped with Hiseq 4000/2500/2000 in different applications, for example, Exome Sequencing, Whole Genome Sequencing, Transcriptome sequencing and Metagenomics sequencing, etc.
System specifications:
Up to 1200 Gb output range, up to 6B reads per run, and 2 x 50 bp, 2 x 100 bp, 2 x 150 bp, and 2 x 250 bp read length
Illumina HiSeq Platform
HiSeq X Ten
The HiSeq X System is the world’s first sequencer to break the $1,000 genome barrier for human whole genome sequencing (WGS). By providing ultra-high throughput and a low price point per genome, the HiSeq X System provides an opportunity to reshape the economics and scale of WGS for both human and non-human species. The HiSeq X System is especially powerful for population-scale WGS. Equipped with the powerful Illumina HiSeq X systems, Novogene is capable of sequencing up to 54,000 human genomes per year. Being one of the first few companies adopting HiSeq X Ten since early 2014, we have extensive experience providing whole genome sequencing service on this powerful system, having successfully sequenced tens of thousands of genomes with high quality results.
System specifications:
1.6 – 1.8 Tb output range, 5.3 – 6 B reads per run, and 2 x150 bp max read length
Computing Platform
Our supercomputing capability allows us to analyze 280,000 whole human genomes per month. This capability aligns with our unsurpassed NGS capacity, enabling us to run many projects of different sizes and still deliver the data to our customers in a timely fashion. Our state-of-the-art platform is comprised of DELL computing nodes with total memory of 410 TB, computing power of up to 1,727 T flops, and Isilon storage capacity of 62 PB. Our storage capacity can expand as our needs grow, ensuring our customers’ data is backed up and available as needed.
