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The Genetic Landscape of Hepatocellular Carcinoma: The Role of One Oncogene.


The arrival of next-generation sequencing technologies has allowed researchers from multiple fronts to scrutinize the genetic basis of multiple diseases, one of the most studied ones being cancer. Hepatocellular carcinoma still remains a significantly mortal type of liver cancer, a constant challenge for research teams to understand its intricacies. Here we will introduce the excellent work “Genomic Sequencing Identifies WNK2 as a Driver in hepatocellular carcinoma and a Risk Factor for Early Recurrence” of Jian Zhou, who is a researcher with an extensive history in liver cancer research. In this study, they studied particularly in the diagnosis and therapeutic targets in hepatocellular carcinoma, and others, identified a potential oncogenic driver in a large Chinese cohort of HCC patients, with the use of sequencing technology provided by Novogene. Its underexpression might be related, among many others, in the development of this malignant cancer.


Hepatocellular carcinoma (HCC) is the most common type of primary liver malignancy and a leading cause of mortality among the different types of cancer. In the United States, it represents the ninth leading cause of cancer deaths [1]. It is more common in men than women and more prevalent in Eastern and Southern Asia and Middle and Western Africa. Frequently, HCC is associated with chronic liver conditions, originated from several risk factors associated with an increased incidence of HCC, such as chronic viral hepatitis (hepatitis B and C, for example), excessive alcohol intake and environmental exposure to aflatoxin and aristolochic acid.

For more information, please download the case study here!