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Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways

Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways

Year : 2020 | Category : Human, Application: Exosome Small RNA Sequencing

Visit: https://www.nature.com/articles/s41388-019-0996-y

Exosomes are exosomes produced in the cytoplasm and released by the cell membrane. The diameter of exosomes ranges from 30 nm to 100 nm. It is widely distributed in blood, saliva, urine, cerebrospinal fluid, milk and other body fluids. In recent years, exosomal RNA has played an important role in the research on the pathogenesis of tumor, immune, neurological, cardiovascular and other diseases, which has important guiding significance for the early diagnosis, prevention and treatment of diseases, and has become a research hotspot.

Exosomes play an important role in intercellular communication and regulation of tumor microenvironment by delivering their contents to recipient cells. Studies have shown that hypoxic environments can alter the transfer of genetic material by tumor exosomes, thereby regulating intercellular communication to affect immune cell function. However, the mechanism by which tumor exosomes promote immunosuppressive microenvironments is not yet clear. To investigate whether hypoxia also affects the genetic material of glioma-derived exosomes TAM polarization was induced and its function was regulated. By sequencing exosome smallRNA, this study successfully revealed the mechanism of TAM polarization induced by mirna-1246, an exosome derived from glioma, under hypoxia.

Figure: Schematic model showing that hypoxic exosomal miR-1246 polarizes M2 macrophages to promote glioma progression.

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