The imperative role of Next-Generation sequencing within Aging
The aging bone marrow (BM) is an essential field of study, with an ever-growing interest among fellow scientists. The nine ‘hallmarks of aging’ together determine the aging phenotype, and based on these, continued efforts are being made to investigate the age-related changes observed within the BM. “Inflammaging” is considered as a low-grade state of inflammation associated with aging, and whilst the possible mechanisms by which aging occurs are now largely understood, the processes leading to the underlying changes within aged BM remain elusive.
Combining both the fields of NGS and aging, we can employ molecular-level applications to not only determine genomic base changes but provide transcriptional profiling (RNA-seq), as well as a high-throughput analysis of DNA–protein interactions (ChIP-seq). Utilising NGS to explore the genetic alterations occurring over the aging process within alterative cell types facilitates the comprehension of the molecular and cellular changes influencing the dynamics of aging BM.
In this webinar, we are delighted to present the highlights of the current review published in November 2021 within the International Journal of Molecular Sciences, written by Dr Shelly Pathak of Novogene Europe and Dr Payal Ganguly of the University of Leeds. The main presentation will be followed by a Q&A session.
Free Webinar: Thursday 10th March 2022, 10:00 AM GMT / 11:00 AM CET