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NovoFocus™ CRC 2.0

NovoFocus™ CRC 2.0 Test is a next generation sequencing (NGS)-based assay that analyzes 50 genes related to Colorectal Cancer (CRC) for clinically important alterations at the DNA level and some other genes for Microsatellite Instability (MSI) status. These genes are known to be relevant for the diagnosis and/or treatment of various CRC according to National Comprehensive Cancer Network (NCCN) guideline and the medical literature.

Parameters

NovoFocus™ CRC 2.0
Cancer Type Colorectal Cancer
Sample Type FFPE Blood /
Plasma (Extracted DNA)
Turnaround Time 14 Calendar Days
Novogene Quality Assurance
Comprehensive Results

NovoFocus™ CRC 2.0 interrogates the complete coding region of 50 genes and introns of 10 genes. It can detect genomic abnormalities (SNV, InDel, CNV and Fusion) and MSI and provide targeted therapy/immunotherapy options. Besides, it analyzes pharmacogenomics and provides chemotherapy options.

Reliable Performance

Comprehensive analytical validation has been completed and the test includes rigorous quality control measures.

Competitive Price

With leading-edge sequencing solutions and superior process efficiency, Novogene offers highly competitive prices for all our service.

Who Benefit from NovoFocus™ CRC 2.0?

NovoFocus™ CRC 2.0 is suitable for all CRC patients, especially for the following:

  • Patients newly diagnosed with Colorectal Cancer (CRC)
  • CRC patients with drug resistance to multiple types of chemotherapy
  • CRC patients planning to use targeted therapy
  • CRC patients who are treated with chemotherapies and would like to know the efficacy and toxicity of these drugs

Workflow

What Clinical Information Does NovoFocus™ CRC 2.0 Provide?

Provide the information about relevant biomarkers and genomic alterations to help match patients to targeted therapies.

Provide the SNP information related to efficacy and toxicity of chemotherapies.

Gene list

50 genes on targeted therapy
ABCG2 AKT1 ALK APC BRAF C8orf34 CCND1 CDK4 CDK6
DDR2 DPYD EGFR ERBB2 ERCC1 FBXW7 FGFR1 FGFR2 FGFR3
GNA11 GNAQ GSTP1 HRAS JAK1 JAK2 JAK3 KIT KRAS
MAP2K1 MAP2K2 MET MTHFR MYC NRAS NTRK1 NTRK2 NTRK3
PDGFRA PIK3CA POLD1 POLE PTEN RAF1 RET ROS1 SMO
TP53 TSC1 UGT1A1 XPC XRCC1

9 genes on chemotherapy
ABCG2 C8orf34 ERCC1 GSTP1 MTHFR TP53 UGT1A1 XPC XRCC1