New platform drives industry forward and opens up a new era for NGS technology
Novogene recently announced Falcon, the first intelligent delivery platform for high-throughput Next Generation Sequencing (NGS). This platform represents a breakthrough in traditional NGS and will shape NGS industry standards and drive the future development of the NGS ecosystem. It will provide customers with an intelligent, efficient and robust service to help meet their sequencing requirements.
“Leveraging our years of expertise in genomic sequencing has enabled Novogene to develop and launch the first intelligent multi-product NGS delivery platform, which will provide a cutting-edge sequencing solution for customers. As a safe and accurate one-stop ground-breaking solution, Falcon enables faster delivery with a more stable quality. As a leading provider of genomic services and solutions in the world, we want to be better positioned to drive innovation in the industry, to lead the industry in the direction towards becoming digital and automated, to propel the establishment of industry standards, and to eventually achieve intelligent transformation”, said Dr. Li Ruiqiang, founder and CEO of Novogene.
Setting a new benchmark for NGS with intelligent technologies
Being intelligent is the cornerstone of Falcon. Over the years, NGS has become the mainstream commercial sequencing method thanks to its high throughput, fast sequencing speed, high flexibility and versatility. However, traditional NGS processes require manual or semi-manual operation by lab workers.
Falcon automates and optimizes NGS procedures. It’s designed to eliminate silos and blockages in NGS operations, from sample extraction and quality control to library preparation, library quality control, library pooling, and all the way to bioinformatics analysis.
Through this intelligent automation, Falcon is able to realize the concurrent delivery of four product types (WGS, WES, RNA-seq and library construction) and significantly improve the delivery cycle and data quality. In the future, more product types will be added.
Falcon’s platform is based on efficient data transmission and machine recognition to achieve accurate control, real-time monitoring and dynamic optimization of production, to ensure 24-hour round-the-clock production.
Creating a breakthrough delivery cycle and scale with a higher efficiency
The key advantage of Falcon is efficiency. The fully automated delivery platform processes samples far more efficiently than traditional human-assisted, single-process and semi-automated production lines. It can process 2,000 to 3,000 full-process samples a day, reducing the production cycle by an average of 60%. Its automated design ensures efficient 24-hour operations and guarantees the production cycle of major projects. For example, it takes 16 days from library construction to data delivery for a RNA-seq library construction project for a research institute with 500 standard samples using traditional methods. Falcon can do this in 90 hours.
Falcon can further improve efficiency through workforce management, reducing labor costs by up to 70% and doubling output stability. Through digital innovation, Novogene will unleash staff productivity to focus on developing many more innovative solutions.
Ensuring a reliable quality with a more stable performance
Reliability and stability are at the core of Falcon’s competitiveness. Sample contamination is a major problem affecting the accuracy of sequencing results in NGS. As an intelligent and fully automated production line, Falcon ensures extremely high reliability and stability throughout the process. The platform uses machine analysis to analyze and differentiate samples without human intervention. This avoids contamination in the sequencing process leading to an accuracy of up to 99.99%.
Falcon adopts two quality control steps: one is in the sample extraction step, and the other is in the library quality control step. It automatically chooses and matches the corresponding standards for different products, and simultaneously performs data recognition and diagnosis. All the sequencing results are evaluated by machine to ensure objectivity and effectiveness wherever possible. Combined with a stable production process this helps to increase the pass rate of NGS library construction by 5%.
To ensure full traceability throughout the production process a unique tracking code is generated for each sample. This enables customers to check a project’s progress at any time.
Novogene will continue to migrate more product lines to Falcon. This will be alongside new product launches and upgrading infrastructure to increase throughput and capacity. By leveraging its many years of expertise, Novogene will continue to explore push the boundaries of NGS and help to define industry standards, to strive for breakthroughs in productivity, stability and quality.
Founded in 2011, Novogene is a leading provider of genomics services and solutions in the world. Headquartered in Beijing, Novogene is doing business in over 60 countries and regions across 6 continents, serving over 4,000 clients. As the leader of genomic sequencing industry in China, Novogene provides services for fundamental researches in life sciences, for medical researches and technologies, and for library construction and sequencing platform building. We also provides sequencing, mass spectrometry (MS) and bioinformatics services for research universities, research institutes, hospitals, drug developers, and agricultural enterprises around the world.