Leading Edge Genomic Services & Solutions



Novogene is a leading provider of cutting-edge NGS services that generates the highest quality data in this market. The results that we have generated have been included in a substantial number of published articles in prestigious journals. Below is a selected list of publications.


Architecture of African Swine Fever Virus and implications for viral assemblyWang N, et al.Science11/1/2019
Stress-induced metabolic disorder in peripheral CD4+ T cells leads to anxiety-like behaviorFan K, et al.Cell10/31/2019
Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord InjuryZhao C, et al.Drug Design, Development and Therapy10/25/2019
The chromosome-scale reference genome of black pepper provides insight into piperine biosynthesisHu L, et al.Nature Communications10/16/2019
The allotetraploid origin and asymmetrical genome evolution of common carp Cyprinus carpioXu P, et al.Nature Communications10/11/2019
Zearalenone Exposure Induces the Apoptosis of Porcine Granulosa Cells and Changes Long Noncoding RNA Expression To Promote Antiapoptosis by Activating the JAK2–STAT3 PathwayZhang FL, et al.Journal of Agricultural and Food Chemistry10/7/2019
Long Read Single-Molecule Real-Time Sequencing Elucidates Transcriptome-Wide Heterogeneity and Complexity in Esophageal Squamous CellsCheng YW, et al.Frontiers in Genetics10/4/2019
Development and Genome Sequencing of a Laboratory-Inbred Miniature Pig Facilitates Study of Human Diabetic DiseaseZhang L, et al.iScience9/27/2019
Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphomaLi Z, et al.Nature Communications9/16/2019
Biallelic SUN5 Mutations Cause Autosomal-Recessive Acephalic Spermatozoa SyndromeZhu F, et al.American Journal of Human Genetics9/15/2019
Genomic analyses reveal selection footprints in rice landraces grown under on‐farm conservation conditions during a shortterm period of domesticationCui D, et al.Evolutionary Applycations9/9/2019
Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal CarcinomaYou R, et al.Cancer Research9/4/2019
Chromosome-level genome assembly of the razor clam Sinonovacula constricta (Lamarck, 1818) Ran Z, et al.Molecular Ecology Resources9/4/2019
A circRNA signature predicts postoperative recurrence in stage II/III colon cancerJu HQ, et al.EMBO Molecular Medicine9/2/2019
Clam genome sequence clarifies the molecular basis of its benthic adaptation and extraordinary shell color diversityYan X, et al.iScience8/30/2019
B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesisLi Y, et al.Nature Communications8/22/2019
The chromosomal-level genome assembly and comprehensive transcriptomes of Chinese razor clam (Sinonovacula constricta) with deep-burrowing life style and broad-range salinity adaptationDong Y, et al.BioRxiv8/15/2019
iTRAQ-based proteomic analysis reveals the accumulation of bioactive compounds in Chinese wild rice (Zizania latifolia) during germinationChu C, et al.FOOD CHEMISTRY8/15/2019
Evolution of the RNA N6-methyladenosine methylome mediated by genomic duplicationMiao Z, et al.Plant Physiology8/13/2019
RNA methylomes reveal the m6A-mediated regulation of DNA demethylase gene SlDML2 in tomato fruit ripeningZhou L, et al.Genome Biology8/6/2019
Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomasZhang Q, et al.Gut8/2/2019
Single-Cell RNA-Seq of the Developing Cardiac Outflow Tract Reveals Convergent Development of the Vascular Smooth Muscle CellsLiu X, et al.Cell Reports7/30/2019
Dasatinib ameliorates chronic pancreatitis induced by caerulein via anti- T fibrotic and anti-inflammatory mechanismZeng XP, et al.Pharmacological Research7/26/2019
Genomic Sequencing Identifies WNK2 as a Driver in hepatocellular carcinoma and a Risk Factor for Early RecurrenceZhou SL, et al.Journal of Hepatology7/23/2019
Study on the Antihypertensive Mechanism of Astragalus membranaceus and Salvia miltiorrhiza Based on Intestinal Flora-Host MetabolismHan C, et al.Evidence-Based Complementary and Alternative Medicine7/21/2019
The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progressionQian Y, et al.Science Advances7/17/2019
SET Domain–Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell QuiescenceYe S, et al.Cancer Research7/15/2019
Genome assembly provides insights into the genome evolution and flowering regulation of orchardgrassHuang L, et al.Plant Biotechnology Journal7/5/2019
A draft genome for Spatholobus suberectusQin S, et al.Scientific Data7/4/2019
Draft genome sequence of cauliflower (Brassica oleracea L. var. botrytis) provides new insights into the C genome in Brassica speciesSun D, et al.Horticulture Research7/1/2019
Draft genome sequence of cauliflower (Brassica oleracea L. var. botrytis) provides new insights into the C genome in Brassica speciesSun D, et al.Horticulture Research7/1/2019
Characterization of the developmental dynamics of the elongation of a bamboo internode during the fast growth stageWei Q, et al.Tree Physiology7/1/2019
An impact of HP1γ on the fidelity of pre-mRNA splicing arises from its ability to bind RNA via intronic repeated sequencesRachez C, et al.BioRxiv6/28/2019
Long noncoding RNA Neat1 modulates myogenesis by recruiting Ezh2Wang S, et al.Cell Death and Disease6/26/2019
A personal and population-based Egyptian genome referenceWohlers I, et al.BioRxiv6/24/2019
An ultra-high-density genetic map provides insights into genome synteny, recombination landscape and taproot skin colour in radish (Raphanus sativus L.)Luo X, et al.Plant Biotechnology Journal6/20/2019
Proteomic analysis of murine bone marrow derived dendritic cells in response to peste des petits ruminants virusLi L, et al. Research in Veterinary Science6/20/2019
Spliceosome disassembly factors ILP1 and NTR1 promote miRNA biogenesis in Arabidopsis thalianaWang J, et al.Nucleic Acids Research6/19/2019
Comparative proteomic analysis of two sesame genotypes with contrasting salinity tolerance in response to salt stressZhang Y, et al.Journal of Proteomics6/15/2019
Benefits of using genomic insulators flanking transgenes to increase expression and avoid positional effectsPérez-González A, et al.Scientific Reports6/11/2019
Genome-wide identification of droughtresponsive microRNAs in two sets of Malus from interspecific hybrid progeniesNiu C, et al.Horticulture Research6/8/2019
Transcriptome analysis based on a combination of sequencing platforms provides insights into leaf pigmentation in Acer rubrumChen Z, et al.BMC Plant Biology6/6/2019
Phylogenomics Reveals an Ancient Hybrid Origin of the Persian WalnutZhang BW, et al.Molecular Biology and Evolution6/4/2019
Uncovering anthocyanin biosynthesis related microRNAs and their target genes by small RNA and degradome sequencing in tuberous roots of sweetpotatoHe L, et al.BMC Plant Biology6/3/2019
Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosisWang D, et al.Molecular Genetics & Genomic Medicine5/29/2019
Mesenchymal stem cell derived EVs mediate neuroprotection after spinal cord injury in rats via the microRNA-21-5p/FasL gene axisZhou X, et al.Biomedicine & Pharmacotherapy5/16/2019
Microbial mechanisms in the reduction of CH4 emission from double rice cropping system amended by biochar: A four-year studyWang C, et al.Soil Biology and Biochemistry5/16/2019
Phylogenomic analysis resolves the relationships among net‐winged beetles (Coleoptera: Lycidae) and reveals the parallel evolution of morphological traitsKusy D, et al.Systematic Entomology4/29/2019
Genome-Wide DNA Methylome and Transcriptome Analysis of 
Porcine Intestinal Epithelial Cellsupon Deoxynivalenol Exposure.
Wang H, et al.Journal of Agricultural and Food Chemistry4/23/2019
HLA‐B*35:01 Allele Is a Potential Biomarker for Predicting Polygonum multiflorum–Induced Liver Injury in HumansLi C, et al.Hepatology4/15/2019
The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin BiosynthesisZhao Q, et al.Molecular Plant4/14/2019
KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27aXong L, et al.Nature Communications4/9/2019
Genome of Crucihimalaya himalaica, a close relative of Arabidopsis, shows ecological adaptation to high altitudeZhang T, et al.PNAS4/2/2019
The wild sweetpotato (Ipomoea trifida) genome provides insights into storage root developmentLi M, et al.BMC Plant Biology4/1/2019
Identification of functional butanol-tolerant genes from Escherichia coli mutants derived from error-prone PCR-based whole-genome shufflingHe X, et al.Biotechnology for Biofuels4/1/2019
The WRKY transcription factor GhWRKY27 coordinates the senescence regulatory pathway in upland cotton (Gossypium hirsutum L.)Gu L, et al.BMC Plant Biology3/29/2019
Independent Microevolution Mediated by Mobile Genetic Elements of Individual Clostridium difficile Isolates from Clade 4 Revealed by Whole-Genome SequencingWu Y, et al.mSystems3/26/3019
Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota MaintenanceCHen K, et al.Cell Host & Microbe 3/19/2019
Diacylglycerol kinase and associated lipid mediators modulate rice root architectureYuan S, et al.New Phytologist 3/18/2019
Analyses of 202 plastid genomes elucidate the phylogeny of Solanum section PetotaHuang B, et al.Scientific Reports3/14/2019
Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant developmentVain T, et al.PNAS3/8/2019
Exogenous adrenocorticotropic hormone affects genome-wide DNA methylation and transcriptome of corpus luteum in sows.Zhao F, et al.FASEB Journal2/27/2019
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinomaJiang Y, et al.Nature2/27/2019
New Genotypes and Phenotypes in Patients with 3 Subtypes of Waardenburg Syndrome Identified by Diagnostic Next-Generation SequencingLi W, et al.Neural Plasticity2/27/2019
l-Rhamnose Metabolism in Clostridium beijerinckii Strain DSM 6423Diallo M, et al.Applied and Environmental Microbiology2/20/2019
The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1Fu J, et al.Frontiers in Microbiology2/14/2019
Characterization of the extra copy of TPOX locus with tri-allelic patternYang Q, et al.BMC Genetics2/14/2019
The sequence and de novo assembly of Oxygymnocypris stewartii genomeLiu H P, et al.Sciencific data2/5/2019
Gut microbiota dysbiosis contributes to the development of hypertensionLi J, et al.Microbiome2/1/2019
Preliminary exploration of potential molecular therapeutic targets in
 recurrent and metastaticparathyroid carcinomas
Cui M, et al.International Journal of Cancer2/1/2019
Preliminary exploration of potential molecular therapeutic targets in 
recurrent and metastaticparathyroid carcinomas
Cui M, et al.International Journal of Cancer2/1/2019
PKCζ facilitates lymphatic metastatic spread of prostate cancer cells in a mice xenograft modelZang G, et al.Oncogene1/31/2019
Penaeid shrimp genome provides insights into benthic adaptation and frequent moltingZhao X, et al.Nature Communications1/21/2019
Effect of purslane (Portulaca oleracea L.) extract on anti-browning of fresh-cut potato slices during storageLiu X, et al.FOOD CHEMISTRY1/18/2019
Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritisJi Q, et al.Nature Communications1/18/2019
Effect of purslane (Portulaca oleracea L.) extract on anti-browning of fresh-cut potato slices during storageLiu X, et al. Food Chemistry1/18/2019
Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis.Ji Q, et al.Nature Communications1/18/2019
http://genome.cshlp.org/content/29/2/250Festuccia N, et al.Genome Research1/17/2019
Comparative Population Genomics of Bread Wheat (Triticum aestivum) Reveals Its Cultivation and Breeding History in China.Chen H, et al.BioRxiv1/14/2019
The sequence and de novo assembly of hog deer (Axis porcinus) genomeWang W, et al.Sciencific data1/8/2019
Hybrid sequencing-based personal full-length transcriptomic analysis implicates proteostatic stress in metastatic ovarian cancerJing Y, et al.Oncogene1/7/2019