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Consistent, Comprehensive, Efficient: An Improved Human Exome Sequencing Solution

Consistent, Comprehensive, Efficient: An Improved Human Exome Sequencing Solution

Introduction
A co-hosted webinar by Novogene and IDT educating researchers and investigators on the latest innovations and breakthroughs with NGS technologies. This webinar will consist of presentations by IDT and Novogene, followed by a live Q&A session.

Time
Wednesday, August 5th, 10:30 am-11:30 am PDT | 1:30 pm-2:30 pm EDT

Speakers
Ryan Demeter, NGS Field Application Manager, Integrated DNA Technologies, Inc.
Manoj Tripathy, Technical Support Scientist, Novogene Corporation Inc.

IDT’s Presentation Description (~25 minutes)

The xGen™ Exome Research Panel v2 is updated with the latest human genome build (hg38) and sequence annotation (RefSeq109), spanning a 34 Mb target region of the human genome. IDT’s new target-aware algorithm and proprietary off-target analysis were used to design the xGen Exome Research Panel v2, resulting in deep and comprehensive coverage across the entire target space. Compared with other commercially available human exome panels, the xGen Exome Research Panel v2 provides an exceptional on-target rate and complete coverage of the human exome as well as offering greater flexibility in multiplexing levels. In addition, large-scale production using IDT’s synthesis platform provides a unique advantage over other array-based synthesis platforms by delivering consistency over time.

    xGen Exome Research Panel v2 is updated with IDT’s new design algorithm as well as the latest human genome assembly (hg38) and sequence annotation (RefSeq109).
    xGen Exome Research Panel v2 provides a superior on-target rate and the most complete coverage of the human exome.
    Our deep coverage and high capture efficiency reduce sequencing costs.
    Individual probe synthesis and QC ensures consistent lot-to-lot performance, which minimizes expensive revalidation.

Novogene’s Presentation Description (~25 minutes)

The exome comprises the protein-coding regions of the genome responsible for most of the exhibited phenotypes. For example, in humans, only 2% of the human genome contains ~85% of known disease-related gene variants. Whole-exome sequencing (WES) is a cost-effective next-generation sequencing (NGS) method to detect protein-coding variants of the genome. The exome enrichment method comprehensively covers the coding region and identify coding variants with applications ranging from population genetics, genetic disease, and cancer studies. Moreover, this method has the capability to expand targeted content to include untranslated regions (UTRs) and microRNA for a more comprehensive view of gene regulation. Sequencing only the coding regions of the genome enables researchers to focus their resources on the genes most likely to affect phenotype and offers an accessible combination of turnaround time and price.

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